Biomerix

REVIVE acts as an ideal tissue scaffold facilitating rapid, fibrovascular tissue ingrowth for a high-quality tissue repair

Approximately one to two months following a soft tissue repair procedure, the amount and degree of fibrocollagenous tissue deposition and the number of multinucleate giant cells adjacent to REVIVE stabilize¹. These preclinical results indicate that a rapid remodeling response occurs.

• Elicit minimal foreign body response
• Encourage robust angiogenesis
• Facilitate optimal tissue ingrowth
• Minimize mesh shrinkage
  • Significant mesh shrinkage following incorporation into the host tissues can lead to long-term patient discomfort and in extreme cases, can necessitate removal of the prosthesis. A number of preclinical studies focused on the event of mesh shrinkage, or passive compression, demonstrate that traditional flatsheet polypropylene meshes contract approximately 30% to 50% of their original size within 2 to 6 months post-implantation, whether made of lightweight, midweight or heavyweight polypropylene^{3, 4}. In preclinical studies, REVIVE showed an average of only 15% shrinkage from the pre-implant size at 6 months post-procedure.

• ¹ Based on preclinical data on file with manufacturer.
• ² Dr. Stephen F. Badylak, "In vivo Evaluation of Biomerix Polypropylene Composite Mesh in a Rat Abdominal Wall Model: 2007-2008"—McGowan Institute for Regenerative Medicine at the University of Pittsburgh - Memo of Historical Controls."
• ³ Klinge et al. "Shrinking of polypropylene mesh in vivo: an experimental study in dogs." European Journal of Surgery (1998); 164:965-969.
• ⁴ Scheidbach et al. "In vivo studies comparing the biocompatibility of various polypropylene meshes and their handling properties during endoscopic total extraperitoneal (TEP) patchplasty: an experimental study in pigs." Surgical Endoscopy (2004); 18(2):211.

Download REVIVE™ Clinical Case Study — Inguinal Hernia Repair via TEP Approach